Buffalo Bills: Updated game-by-game predictions entering the 2021 season

Week 15: Carolina Panthers at Buffalo Bills

The Buffalo Bills return home to face their third NFC South opponent in four weeks as they face the Carolina Panthers. There is no denying these two franchises are closely tied together since Sean McDermott and Brandon Beane have joined the Bills after previously being with the Panthers.

This is a different Panthers team though as they have seen enough turnover with new head coach (Matt Rhule) and new quarterback (Sam Darnold). The Panthers also will have star running back Christian McCaffrey back this year and he is a player that will give opposing defenses problems this year.

However, the Panthers have some questions on defense, and in their secondary, and the Buffalo Bills offense should be able to score enough to secure the win.

Prediction: Win (11-3)

Week 16: Buffalo Bills at New England Patriots

At this point in the season, playoff and division-clinching scenarios will absolutely be in play. If the Buffalo Bills have already won 11 games to this point, there is a real possibility they could have the AFC East title in their sights and even potentially clinch it here against New England.

If that is the case, there is no question this team will be focused and looking for their second consecutive division title. This will be enough for the Buffalo Bills to sweep the New England Patriots for the second straight year.

Prediction: Win (12-3)