Buffalo Bills: Game-by-game predictions for the 2021 season

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ORCHARD PARK, NEW YORK – JANUARY 09: Micah Hyde #23 of the Buffalo Bills bats down a Hail Mary pass thrown by Philip Rivers #17 of the Indianapolis Colts (not pictured) during the second half of the AFC Wild Card playoff game at Bills Stadium on January 09, 2021 in Orchard Park, New York. The Bills won 27-24. (Photo by Bryan M. Bennett/Getty Images) /

Week 11: Indianapolis Colts at Buffalo Bills

The Buffalo Bills faced the Indianapolis Colts in a rematch of the AFC Wild Card game from this past season. The Colts made a pretty significant change this offseason by trading for Carson Wentz to replace Philip Rivers, who retired after the season.

While Wentz is going to be a pivotal piece to the Colts’ success, this is still a very good football team with a strong offensive line, good run game and a stout defense. This is probably the Bills’ toughest opponent since facing the Titans in Week 6 and this is the game where the winning streak ends.

Prediction: Loss (8-2)

Week 12: Buffalo Bills at New Orleans Saints

After the opening game on Thursday night in Week 1, the Thanksgiving primetime game is probably the second biggest regular-season game for the NFL. The Buffalo Bills are now set to be in that game and will face the New Orleans Saints.

This is likely going to be a very different Saints team with Drew Brees no longer under center and there are questions about whether it is Jameis Winston or Taysom Hill replacing him. Even without the future Hall of Famer, this is still a very good team and will be a tough game for the Bills.

However, Josh Allen is undefeated on Thanksgiving and until he loses, I pick the Buffalo Bills.

Prediction: Win (9-2)

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