This is a must win for both teams. This game is also being played in Toronto, so it is a home game as much for the Seahawks as it is for the Bills or an away for both teams. The Bills have been stellar against the run for the past 3 games, only giving up 2.9 yards per carry and holding Jackson to only 64 yards last week against the Rams. The Seahawks have allowed a little bit more per game ranging in the 4.7 range. This bodes well for the Bills as it will allow CJ Spiller to do what he does best, create space, get to the edge and make things happen. The downfall for the Bills here is the pass defense. Russell Wilson threw for 293 yards last week against the Bears. The Bills passing defense has ranked in the lower half of the league for the entire season. Mario Williams will have to get to Wilson to help the back seven out. The Bills and Seahawks are just about equally matched and the Seahawks have not played well on the road this year, plus for the Bills. This should be a good game and a close one. Bills win 27-21.