Fitzpatrick and company need to get themselves together and start catching the ball if something is going to resurrect the passing game. As for the running game Fred Jackson and CJ Spiller are listed as 100% and are ready to go. This will be a game that I think you see one big ground play from the Bills and a countered big ground play from the 49ers. The powerhouse 49ers and Frank Gore have been able to put together an impressive average of 167 yards/game on the ground throughout the first 4 games of the season. With Kraig Urbik, LG, out for the game today along with Cordy Glenn, LT, the once impenetrable and cohesive offensive line will have some questions on board this game. Chad Rhienhart is questionable for the game but is first to come off the bench. If Rhinehart cannot go with his ankle then look for Chris Brown, the only other interior lineman to start and pray that there is not another injury within the middle three. This could cause a problem for the cohesiveness of the O-Line that could hurt the pass protection as well as the running game. Spencer Johnson is the only other player out at this point. There are a couple of players that are listed as questionable but should be able to go, those being Jarius Byrd, and reserve WR Ruvell Martin. Scott Chandler and Donald Jones are the only two listed as probable. Those last four we should see on the field today unless there were some setbacks during warm-ups.